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A method for simulation of the roller compaction process using a laboratory scale compaction simulator was developed. The simulation was evaluated using microcrystalline cellulose as model material and ribbon solid fraction and tensile strength as key ribbon properties. When compacted to the same solid fractions, real and simulated …
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Friction between the rolls and the powder allows the rolls to grip the powder and drive it toward the gap, compacting it into a thin strip ("ribbon") that is then broken …
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Roller compaction is a dry granulation process for manufacturing solid drug formulations. A flowing powder is continuously fed into the counter-rotating rolls and …
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The powders are compacted into a ribbon or small pellets between these rollers and milled through a low-shear mill. Read On The applied press force during roller compaction is called the 'specific press roller force', specified in kN/cm; the minimum distance between the press rollers is the gap [mm].
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The effect of lubrication on density distributions of roller compacted ribbons. Int. J. Pharm. (2008) B.A. Patel et al. Predicting the pressure distribution during roll compaction from uniaxial compaction measurements ... due to the complexity of breakage behaviour in ribbon mills it is difficult to predict the size distribution based directly ...
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The relative density of ribbons and riblets produced using a roller compactor and compaction simulator, respectively, was investigated using pycnometry to determine the correction factor Kp (Reimer and Kleinebudde, 2019).The ribbons and riblets were produced at specific compaction forces between 1 and 12 kN/cm and, as expected, their …
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1. Introduction. Roller compaction (RC) is a continuous dry granulation process in which the powder is fed and compressed at high pressure using two counter rotating rollers to produce a compacted sheet of powder called a ribbon or flake.
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A number of reports have investigated the use of NIR (near infrared) spectroscopy for monitoring roller compacted ribbon density (Acevedo et al., 2012;Gupta et al., 2004Gupta et al.,, 2005 ...
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We used micro-CT to assess uniformity of density of simulated ribbon, taking advantage of its capability for density quantitation [17, 20, [33], [34], [35]].Ribbon images were reconstructed from raw X-ray micro-CT data, which showed relatively uniform density in the simulated ribbon (Fig. 2 a).The X-ray opacity of Y-Z cross sections of the stacking …
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There have been studies conducted on oscillating mill of roller compacted materials that have identified the effects of ribbon porosity on mill quality attributes (Mirtič and Reynolds, 2016; Olaleye et al., 2020; Sun et al., 2018). In these studies, an inverse relationship between tensile strength and porosity, and they observed that milling ...
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Two such DEM-PBM approaches have recently been applied for ribbon mills: the direct approach of Hare et al. [13] and the indirect approach of Loreti et al. [14, 15]. ... Roller compacted ribbons were simulated using the DEM cemented-bond model of [16], based on the Timoshenko beam theory [17]. The ribbons were formed from a sheet …
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Roller compaction milling process was simulated with a lab scale oscillating mill. • Ribbon properties effects on granule size distribution were studied experimentally. ... GSDs obtained from co-milling of roller compacted ribbons at two different densities were used for PBM parameter determination. PBM parameters were determined by fitting ...
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a one step milling process for a roller compacted ribbon and to quantify the effect on overall particle size distribution. METHODS A Freund-Vector Corporation TFC-520 roller …
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A Freund-Vector TFC-520 roller compactor and a Quadro Comil® Model U10 was used to conduct a study to evaluate the effectiveness of a two-step milling process vs. a one-step milling process for a roller compacted …
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0.864 (0.003) The effect of ribbon thickness on generated percent fines by milling simulated MCC ribbons is shown in Fig. 1. When the thickness of ribbons is less than 2.55 mm, the percentage of fines increased linearly with increasing thickness. However, the percent fines generation is approximately constant when the thickness is above 2.55 mm.
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The characteristics of roll-compacted milled granules are set primarily by the ribbon density: studies (Kleinebudde 2004; von Eggelkraut-Gottanka et al. 2002; Inghelbrecht and Paul Remon 1998a, b) have reported that the average granule size is directly proportional to the ribbon density.In addition, as no further compression is …
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The breakage rates of roller compacted ribbons of two pharmaceutical excipients, microcrystalline cellulose (MCC) and mannitol, were determined with two different approaches, i.e. by analysing the ...
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Miguelez-Moran et al. (2008) explored the effect of friction conditions on the properties of roller compacted ribbons and revealed that the heterogeneity of ribbon density distribution is ...
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Granule size distribution (GSD) is one of the critical quality attributes in the roller compaction (RC) process. Determination of GSD for newly developed pharmaceutical compounds with unknown ribbon breakage behaviors at the RC milling step requires a quantitative insight into process parameters and ribbon attributes. Despite its pivotal role …
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Roller compaction milling process was simulated with a lab scale oscillating mill. Ribbon properties effects on granule size distribution were studied experimentally. …
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Roller compaction followed by milling of the generated ribbons is a typical dry granulation route. It is desirable to be able to predict the size distribution of the …
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Density mapping of roller-compacted ribbons using terahertz spectroscopy. Terahertz (THz) spectroscopy and imaging are non-destructive tools for measuring the chemical and physical attributes of pharmaceutical raw materials, intermediates, and finished products [1]. Examples include determining the crystallinity and polymorphism of drug ...
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Porosity of ribbon compacted at 100 bar RC pressure (high σ RC), and consequent tablet porosities following 5 and 20 kN tableting load (low and high σ TS). By using X-ray tomography it was also possible to visualise the granular material within the tablets and determine to what extent the granular structure is maintained during the …
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Mill. The ribbon coming out of the roller compactor is broken into smaller particles in the mill. ... The compacted ribbon was produced using a Fitzpatrick CCS220 roller compactor (Chilsonator) with serrated surface rollers, having a 200mm diameter and 20mm width. The operating variables investigated were roll force and roll speed.
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Transfer and scale-up of roller compaction processes based on conservation of ribbon density is relatively well established, although different equipment designs, …
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The manually operated milling bars push material – either in roller compacted ribbon or tablet piece form – through the screens in the milling chamber, with fully processed granules collected in a drawer. The overall Small Scale Mill design emphasizes ease of use with fast and simple fitting and cleaning of all components.
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tages of roller compaction, due to the large dwell time needed for the ribbons to pass through the mill. Passing the ribbons through the .125" followed by the .050" produced the fastest milling time as well as the tightest PSD and low fines for all of the combinations. CONCLUSIONS 0 5 10 15 20 25 30 35 0 200 400 600 800 1000 1200 1400 1600 ...
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Detailed view of a ribbon compacted on sinusoidal rolls. The average roll stress for sinusoidal rolls can be related to the equivalent stress for flat rolls by: (23) ... Shear stresses and material slip in high pressure roller mills. Powder Technology, 122 (2002), pp. 136-144.
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Effects of roller speed on ribbon solid fraction. Table 6 shows the ribbon solid fraction of MCC102 at a constant gap:force of 2 mm:4 kN/cm, at various roller speeds of 2, 4, and 6 rpm. The results show that the solid fraction of the ribbons is not greatly impacted by different roller speeds in the range of 2–6 rpm.
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Roller compaction system and ribbon production. The roller compactor was an Alexanderwerk WP120 (Alexanderwerk, Germany), which incorporates a feeding, compaction, and milling system and is equipped with a de-aeration system that can enhance the powder flowability and play a role in reducing the amount of fines.
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